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how Calciphylaxis can affect your health?



Calciphylaxis is a serious and unusual disease in which calcium builds up in small blood vessels in fat and skin tissue.

Calciphylaxis causes blood clots, painful skin ulcers, and can cause serious infections that can be fatal. People with calciphylaxis often have kidney failure and either undergo dialysis or have a kidney transplant. This condition can also occur in people who do not have kidney disease.



Signs and symptoms of calciphylaxis include:

  • Large purple knit pattern on leather
  • Deep and very painful lumps ulcerate, causing clear pain with dark brown skin and do not heal. It usually occurs in areas of skin with a high fat content, such as the abdomen and thighs, but can occur anywhere.
  • Infections from non-healing wounds



Medicines that help prevent blood clotting such as apixaban (Eliksaban) (anticoagulants) may be prescribed to restore blood flow to the affected tissue.

Hyperbaric oxygen therapy helps increase the oxygen supply to the affected area of the body. Alternatively, the doctor may use a low dose of tissue plasminogen activator (TPA) to dissolve blood clots in small blood vessels in the skin.

  • Dialysis. If you are on kidney dialysis, your doctor may change your dialysis prescription, including the medications you use and the frequency of dialysis.
  • Medication change. Doctors can evaluate current medications, eliminate potential triggers for calciphylaxis such as warfarin, corticosteroids, and iron, and change the amount (dose) of calcium or vitamin D supplements.
  • Medicine. A drug called sodium thiosulfate can reduce calcium deposits in arterioles. It is usually given intravenously three times a week during dialysis. Doctors may also recommend a drug called cinacalcet (Sensipar), which helps control parathyroid hormone (PTH). Other drugs can be used to improve the balance between calcium and phosphorus.
  • Operation. If excess parathyroid glands (hyperparathyroidism) contribute to abnormal calcium metabolism by producing excess PTH, surgery may be recommended to remove all or part of the parathyroid glands.

Calciphylaxis is a significant renal condition that is uncommon. Calcium builds up in the fat and skin’s blood vessels as a result of the disorder. Calcific uremic arteriolopathy is another name for calciphylaxis. People with advanced chronic renal disease are the most likely to develop it.

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