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Why must some medicines be taken on an empty stomach?

Medicines are compounds used to treat or prevent diseases. Medicines can also be used to treat certain ailments or health problems. Medicines can be taken orally, applied locally, injected, inhaled, or injected into body orifices, among other delivery methods.But how will you know which medicines to be taken on an empty stomach or full stomach and why there is a need to take in this manner. In this article,all the things will be covered,why there is a need to take medicine before food and how food influence the effectiveness of drug with or without food.

What happens to the medicines when we eat?


A medicine gets taken into the bloodstream and spread throughout the body when you consume it. The medication achieves its maximum concentration. The drug level drops slowly after that as it is removed from the body.

The active elements in a drug will be broken down by the body as the circulating blood is filtered by the liver or kidneys, and these levels will drop as the body breaks down the active chemicals.Every medicine goes through this basic process.

Because drugs are absorbed faster than the body can break them down, the highest concentration is reached quickly, but it takes longer for the drug to leave the body.

What is drug food interaction?


A drug-food interaction occurs when your food and medicine react to each other. Medications, both prescription and over-the-counter, may interact. These drugs include antacids, vitamins, and iron supplements.

Food has no effect on all drugs. However, what you eat or when you eat it has an impact on certain of them. If you take a medicine with food, your body may not absorb it. Alternatively, certain foods can slow or stop the medication from being absorbed.

Instructions on how to take medicine are frequently included in the package booklet. If you don’t receive one, pharmacists can supply you with the information you need.

Whether medicine is taken before or after eating affects its bioavailability in our systems. The medicine’s effectiveness will be harmed if its bioavailability is low. As a result, it’s vital that you take your prescriptions in the proper sequence.

How foods can have an impact on drug efficacy?


Food can have a variety of effects on the efficacy of medicines:

Emptying rate of the stomach: The rate of stomach emptying will be slowed by fatty foods. The drug’s absorption rate will be reduced if the rate of stomach emptying is reduced.

Food stimulates the production of gastric acid. The stomach produces acid to help in food digestion. Antibiotics like erythromycin, isoniazid, and azithromycin lose their potency when they are exposed to an acidic environment. In an acidic environment, the medication will degrade. As a result, the body will absorb less medicine and the absorption of medicine will be lowered. As a result, the medicine’s efficacy will be harmed. As a result, you should take this drug on an empty stomach.

Calcium and iron are minerals that can be found in some foods. For example, biphosphonates and ciprofloxacin will attach to the minerals and react with them. This is referred to as the chelation process, and it renders the medications inactive. As a result, such medications should be taken before to consuming food.

Alcohol-containing foods and beverages depress the central nervous system. Chlorpheniramine, hydroxyzine, dexchlorpheniramine, and triprolidine are some of the medications that might make you sleepy or drowsy. As a result, such medicines should be avoided when consumed with alcoholic meals or beverages. The effects of the drugs will be amplified if you drink alcohol.

Adsorption on a physical level: Digoxin, for example, is quickly absorbed when consumed with high-fiber meals. As a result, high-fiber foods should be avoided when taking such medications.

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